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Herbs and supplements
for SIBO

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Herbs and supplements for SIBO

Medically reviewed by:
Dr John Freeman

Natural herbs and supplements may have a solid case for inclusion in a recovery plan in SIBO. However, not all are created equally and it’s very important to evaluate fact from marketing fad and hype.

We have done our best to collate the most credible medical for SIBO treatment and management.

When purchasing any supplement or herb, know the difference in the standard of quality is large due to the lack of regulation in the industry. For example, not all supplements although they may contain the same 100% ingredients are created equally. These are compounds of nature and may vary significantly on quality based on suppliers, manufacturing process, and so on which can all impact the bioavailability (ability for the body to metabolise and use the supplement for the intended purpose).


Glutamine is an α-amino acid. It is vital for enterocyte’s (cells of the gut) to metabolise things with ease. Just as carbs are the preferred source of energy for the body, glutamine is the preferred fuel source for the cells that line the gut.[1]

Glutamine may help the cells of the gut lining function more optimally resulting in better digestive health and helping food move through as it should, giving SIBO bacteria less opportunity to thrive.[2]

Guar Gum

Guar gum is a fibre that comes from seed of the guar plant. It is Hydrophilic meaning it takes up water. Guar gum is used for constipation, diarrhea, irritable bowel syndrome (IBS) and there is research to support this.

Guar gum acts as a bulking agent and natural stool softer so maybe of use to people suffering with SIBO and runny or very solid bowel movements as it can both bulk and soften.


Berberine maybe useful to SIBO sufferers. SIBO causes gas in the small intestine that pushes on the walls of the intestine in an abnormal way. This can cause microscope damage or dislocation of the tight junctions leading to leaky gut.[3]

Berberine helps refuse these tight junctions due to its intracellular stabilising effects leading to repairment of the gut lining.[4]


Khellin is derived from the Ammi Visnaga a plant from which multiple medical therapies have been derived.

From Khellin, a drug has come called Intal (used for asthma) has been derived. It works by inhibiting histamine responses by acting on the surface of the lungs.

Histamine issues are common with SIBO, and the theory here is that being an unabsorbable substance, it may have a similar effect on the gut lining as it does on asemantic lungs.

There is some emerging research to support this. Some of the most effective antibiotics used to treat SIBO are also unabsorbable by nature.

Anti-Microbial effects Herbs for SIBO

Oregano oil

Research suggest oregano has potential antibacterial antimicrobial effects. It’s has been used in traditional medicine for this purpose for over 2,500 years.

Oregano oil contains two active compounds that maybe useful in not only SIBO but SIFO. It contains carvacrol, which is antibacterial and thymol, which has antifungal properties and thus may be useful in the treatment of small intestinal fungal overgrowth.[5][6]


Cinnamon is a natural antimicrobial. Cinnamon may therefore assist in killing off the overgrowth of bacteria in the small intestine.[7]


Allici is derived from garlic and has antimicrobial effects that can help kill off overgrowth of bacteria.


Components of the Neem tree contain a huge number of phytochemicals (plant chemicals) that maybe beneficial in treating SIBO and other gut issues.

Neem has been found to kill many types of microbes, including the gram-positive S. aureus and the gram negative E. coli bacteria.

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