Natural herbs and supplements
for SIBO treatment

Herbs and supplements for SIBO – Herbal antimicrobials have been shown in studies to be very effective for those suffering from SIBO. Listed below are some of the most effective and studied natural options for SIBO (small intestinal bacterial overgrowth)

Antimicrobial extracts and oils

FixBIOME ing Red thyme
Red thyme oil (Thymus vulgaris)

Red thyme has strong antimicrobial properties that can help kill off bacterial and fungal overgrowth when formulated in a way that ensures the delicate balance and stability of this powerful essential oil.

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Oregano oil

Oregano has antibacterial and antimicrobial effects. It has been used in traditional medicine for this purpose for over 2,500 years.

Oregano oil is a biofilm buster, and contains two active compounds that maybe useful in not only SIBO but SIFO. It contains carvacrol, which is antibacterial and thymol, which has antifungal properties and thus may be useful in the treatment of small intestinal fungal overgrowth.

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Sage extract (Salvia officinalis)

Sage extract has anti-inflammatory properties and aids in smooth functioning of the digestive system. Sage has been used for treating intestinal cramps, flatulence and indigestion for thousands of years in traditional Chinese medicine.

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FixBIOME ing Lemon balm

Lemon Balm leaf extract (Melissa officinalis)

Lemon balm is a gastro-protective and active ingredient that has anti-inflammatory effects and has been shown to improve digestive symptoms. Lemon balm helps reduce stress and brain fog promoting a stable mood and sense of wellbeing.

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Peppermint oil

Our gut contains lots of smooth muscle tissue to ensure the healthy digestion of foods. Peppermint oil is an antispasmodic used to relieve muscle spasms. It eases the symptoms such as cramping, bloating, excessive flatulence and can reduce nausea.

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Fix No1 – Motility

Take back control of that irritable bowel and improve your gut motility.

Utilising clinically proven ingredients and developed by doctors and approved by naturopaths. Fix No1 is a next generation gut supplement that uses soft gel technology to combine carefully stabilized essential oils, providing a powerful antimicrobial blend. This combination allows for high bioavailability, whilst maintaining stability, to act on the gut and assist in the treatment of IBS, SIBO, parasites and digestive issues.

Antimicrobial herbal extracts

FixBIOME ing Berberine HCL


Berberine is powerful for SIBO. SIBO causes gas in the small intestine that pushes on the walls of the intestine in an abnormal way. This can cause microscope damage or dislocation of the tight junctions leading to leaky gut.
Berberine helps refuse these tight junctions due to its intracellular stabilising effects leading to repair of the gut lining.

Research >
FixBIOME ing Chinese rhubarb root and rhizome

Chinese Rhubarb root and rhizome (Rheum officinale)

Rhubarb can assist in restoring gut microbiota balance, restore disrupted flora, and prevent microbiota shift. Rhubarb has positive effects on intestinal immune activity and our gut makes up the largest portion of our immune system. Rhubarb is used for digestive issues such as constipation, diarrhoea, heartburn and stomach pain. Rhubarb is also an effective antimicrobial.

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FixBIOME ing Indian barberry root

Indian barberry root extract (Berberis aristata, containing berberine)

Indian Barberry has potent antimicrobial activity against major gastrointestinal pathogens.

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FixBIOME ing DGL Licorice

DGL Licorice

DGL licorice soothes your stomach lining and supports adrenal glands. The licorice we formulate with is deglycyrrhizinated (DGL). This means it has minimal effect on your blood pressure compared to regular licorice and is safer for long-term use.

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FixBIOME ing Chinese skullcap root

Chinese skullcap root (Scutellaria baicalensis)

The skullcap assists in calming and nourishing the nerve area of the digestive tract and reducing spasms, pain, and bloating safely and effectively.

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FixBIOME ing Coptis root and rhizome

Coptis root and rhizome extract (Coptis chinensis, containing berberine)

Coptis root has been used to promote healthy digestive and microbial environments. Berberine alkaloids in Coptis have been researched for their influence on microbes in the gut.

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FixBIOME ing Ginger rhizome

Ginger rhizome (Zingiber officinale)

Ginger rhizome helps alleviate the SIBO symptoms by protecting the stomach from oxidative stress-induced damage.

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FixBIOME ing Dill seed

Dill seed

Dill seed aids peristaltic action by eliminating wastes from the body, making it an effective constipation treatment. Additionally, the herb’s antacid characteristic reduces the creation of excessive acids in the stomach, which helps cure indigestion, ulcers, and gastritis while promoting improved nutritional absorption.

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Neem (Azadirachta indica)

Neem has proven to be highly effective in clinical literature for treating SIBO and IBS. With its antibacterial and anti-inflammatory properties, neem helps eliminate harmful bacteria in the stomach and improves digestion. Additionally, neem’s cooling properties aid digestion, while neem bark extracts show promise in treating gastrointestinal ulcers.
The milling process and stabilisation of neem is incredibly important to the dose required for the gut as this ingredient is not designed for maximum absorption, but instead maximum dispersion along the gut lining. FixBIOME has developed a proprietary process for this which aims to optimise its impact on the gut specifically.


Fix No2 – Control

A powerful blend of berberine and Chinese medicinal herbs.

Fix No2 ingredients have been proven to assist restoring gut microbiota balance, restore disrupted flora, and prevent microbiota shift while supporting the gut brain and gut skin axis.
Fix No2 contains Biofilm busting properties to assist in breaking through any mucilage protecting a community of unwanted bacteria and other microorganisms causing dysbiosis and discomfort in the gut. The clinically proven ingredients promote a healthy digestive and microbial environment.

Gut repairing herbal extracts

After a period of SIBO where the gut goes through constant damage and stretching causing loosening of the tight junctions (often leading to leaky gut) it is vital to restore the structural integrity of the gut. That can help reduce relapse rates and restore optimal function of the gut.

Below is a list of clinically studied ingredients and natural compounds.


A lack of zinc is directly linked to damage of the gut membrane barrier. Studies have shown that zinc can assist in tightening a leaky gut.

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L-Glutamine nourishes and supports gut cell regeneration which occurs every 48hrs. L-Glutamine is a major fuel source for enterocytes (intestinal cells and brain cells).
L-Glutamine is a unique amino acid that serves countless major functions in your body.
L-Glutamine has been widely studied and found to support gut health.
L-Glutamine may help the cells of the gut lining function more optimally resulting in better digestive health and helping food move through as it should, giving SIBO bacteria less opportunity to thrive.

Research >
FixBIOME ing DGL Licorice

DGL Licorice

DGL licorice soothes your stomach lining and supports adrenal glands. The licorice we formulate with is deglycyrrhizinated (DGL). This means it has minimal effect on your blood pressure compared to regular licorice and is safer for long-term use.

Research >
FixBIOME ing Marshmallow root

Marshmallow root

Marshmallow root has been studied and found to improve mucous membrane health.
Marshmallow root supports:

  • Coats the digestive tract with a protective lining to support a balanced inflammatory response in the gut
  • Restore cell junctions
  • soothe the stomach lining
  • promote regular bowel movements
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Quercetin can enhance intestinal barrier function and modulates gut microbiota composition. The activities of tight junction proteins at the gut epithelium enhance barrier functions and reduce inflammation, protecting the host from colonic diseases.
Quercetin is a naturally occurring free radical scavenger that supports healthy immune system function.
Studies suggest that quercetin affects the progress of microbiota-associated diseases. Notably, quercetin supplementation increased gut microbial diversity, which may improve gut protection.

Research >

Gut Fix – Repair

An essential for addressing gut issues and repairing the gut.

Gut Fix – Repair takes a three-pronged scientific approach that will have you defeating gut issues & taking back control of your digestive health. Gut Fix works to increase the guts’ ability to absorb nutrients and eases inflammatory skin and immune conditions to promote overall health. Your gut is responsible for nutrient absorption from the foods you eat and supplements you take. Without a healthy gut any supplementation is redundant.

Quality of herbs and natural antimicrobials

When purchasing any supplement or herb, know the difference in the standard of quality is large due to the lack of regulation in the industry. For example, not all supplements – although they may contain the same 100% ingredients – are created equally.

These are compounds of nature and may vary significantly on quality based on factors like suppliers, manufacturing processes, which can all impact the bioavailability (ability for the body to metabolise and use the supplement for the intended purpose).


IBS 6-8 Week Course

In need of a complete gut reset and repair after years of gut issues?

IBS 6-8 Week Course contains the products for 6-8 weeks – our advised duration for SIBO, SIFO and Candida. Effective for SIBO, fungus, candida & leaky gut. With this complete system, you can look forward to easier digestion, reduced bloating, improvement in skin, better gut motility (by constipation or diarrhea), hair health and even a better quality of life.