Gut health

Gut lining

FixBIOME OP Dr James Freeman profile photo

Gut lining

Medically reviewed by:
Dr James Freeman

The importance of repairing your gut lining

The gut is often referred to as the second brain, and for a good reason. The gut lining is home to over 100 million nerve cells, more than any other organ in the body. It’s no wonder that gut health is closely linked to overall health and well-being.

Several things can damage the gut lining, including poor diet, stress, and certain medications. When the gut lining is damaged, toxins and bacteria enter the bloodstream, which can lead to inflammation and a host of other health problems.

That’s why it’s so important to do everything you can to protect and repair your gut lining. This includes eating a healthy diet, reducing stress, and taking supplements that support gut health.

No matter your approach, repairing your gut lining is essential for optimal health. By taking care of your gut, you’re taking care of your entire body.

What is the gut lining?

The gut is a long, coiled tube that runs from the mouth to the anus. It comprises a lining with several layers, including the mucosa, the innermost layer. The mucosa is lined with a thin layer of tissue called the epithelium. Underneath the epithelium is a layer of connective tissue called the submucosa. The submucosa contains blood vessels, lymphatic vessels, and nerves. The gut also has a smooth muscle layer that helps move food through the digestive system.

The mucosa is lined with many different types of cells, including epithelial cells, goblet cells, enteroendocrine cells, and immune cells. The epithelial cells form a barrier between the inside of the gut and the outside world. Goblet cells produce mucus, which lubricates the gut and helps to trap bacteria and other particles. Enteroendocrine cells secrete hormones that regulate digestion. Immune cells help to protect the body from infection.

The gut lining is constantly exposed to food, bacteria, and other particles. To protect the body from these potential dangers, the epithelial cells produce a substance called mucus. Mucus is a sticky, slippery substance that coats the gut lining and traps bacteria and other particles. The goblet cells produce mucus in response to signals from the immune system.

The mucus barrier is constantly renewed. Old mucus is sloughed off into the gut, producing new mucus to replace it. This process is known as mucus turnover. Mucus turnover is essential for maintaining a healthy gut lining.

How important is your gut lining?

Your gut lining is essential for many reasons. It helps to protect your intestines from harmful bacteria and other toxins. It also helps to absorb nutrients from the food you eat. A healthy gut can help improve digestion, boost immunity, and even help to reduce stress levels.

Many studies have revealed that a leaky gut paves the way for the development of autoimmune diseases. Therefore, healing the leaky gut suppresses the symptoms of these diseases; as such, decreasing it from happening is vital to the prevention of autoimmune diseases.

The gut linings connection to diseases

Some studies show that a leaky gut may be associated with other autoimmune diseases such as:

  • Lupus
  • Type 1 diabetes
  • Multiple sclerosis
  • Chronic fatigue syndrome
  • Fibromyalgia
  • Arthritis
  • Allergies
  • Asthma
  • Acne
  • Obesity
  • Mental illness
  • Histamine intolerance
  • Psoriasis
  • Rosacea

How does the gut lining work?

Your gut is lined with cells and mucous. These collectively work together to act as gatekeepers to the rest of your body.

That’s where the gut lining comes in.

The gut lining is made up of layers of cells. It covers a surface area of a whopping 4,000 feet long!

The lining of your gut resembles a net with a few small openings. These tiny holes serve as filters, allowing only specific substances to pass through. It acts as a barrier to block out larger, more dangerous substances.

Your gut is not an impenetrable barrier because it needs to let essential nutrients and substances pass through to reach specific parts of your body that require them most.

The features of your gut lining

  • The mucus layer: This layer helps protect your gut from bacteria and other harmful substances.
  • The cells: The cells of your gut lining help absorb nutrients from your food and keep harmful substances out of your body.
  • The blood vessels: The blood vessels in your gut lining help carry nutrients and oxygen to your gut cells.

Gut problems and the gut lining

Problems with the gut lining can lead to many issues, including inflammation, nutrient deficiencies, and an increased risk of infections.

Your gut is lined with a layer of cells known as the epithelium. This layer is essential for keeping out unwanted substances and bacteria while allowing nutrients to be absorbed into the bloodstream.

In individuals with gut problems, the lining may become too porous, allowing harmful substances to reach the tissues below.


The gut lining is a critical part of the digestive system. The gut lining protects the gut from harmful microbes and other substances that could cause inflammation or disease. When the gut lining is healthy, it helps keep the level of inflammation in the gut normal. The interaction between the gut lining and the microbes in the gut is essential for optimal health.

How SIBO/SIFO candida and gut conditions can damage your gut lining

If you suffer from SIBO or SIFO, the chances are that you also have candida overgrowth. Candida is a type of yeast that lives in your gut, and when it gets out of control, it can damage your gut lining. This can lead to a leaky gut, allowing bacteria and toxins to enter your bloodstream, causing a host of problems.

SIBO is an overgrowth of bacteria in the small intestine, while SIFO is an overgrowth of fungi in the stomach.

Gut problems can damage your gut lining by causing micro-tears in the tight junctions. In the case of SIBO, this results from the overgrowth of bacteria creating gases that stretch the small intestine leading to micro-tears making your gut much leakier than average even post killing the SIBO.

This can allow substances that aren’t supposed to leave your gut to leak out. This condition is called leaky gut.

If you have a leaky gut syndrome, it impacts your overall health, not just your digestive system.

A leaky gut is a condition in which the gut lining is compromised and no longer serves as an effective barrier. Gluten, nasty bacteria and undigested food particles can enter your system through the tiniest openings, growing in size until they can harm your health.